Since January 2025, our URP2496 laboratory has become UMR1333 Santé Orale, with the merger of three other teams URB2i, UMRS1338 and EA7543 LAB-NOF. Our mission remains focused on the orofacial sphere, and covers both the tooth itself (mineralization anomalies, stimulation of pulp repair) and its supporting tissues (periodontium), as well as bone defects of the skull and face. Our objectives are to understand the pathophysiological mechanisms involved, but also to explore and develop new technologies and solutions for the reconstruction of these structures, in order to offer concrete therapeutic solutions to patients.