Presentation

Welcome on the website of the Laboratory “Oral Health” UMRS Inserm 1133 located at the Dental school of Université Paris Cité.
The central theme of the laboratory is the study of orofacial tissues and their reconstruction.

The Oral Health unit’s project aims at investigating the mechanisms underlying chronic oral pathologies (caries, periodontitis…) and rare disorders related to the mineral metabolism, which affect both the skeleton and the tooth mineralization (X-linked hypophosphatemia, Pseudohypoparathyroidism, Tight junction related disorders…). The team develops new therapies to repair the oro-facial defects resulting from these chronic and rare pathologies, including tissue engineering strategies or new medical devices. Furthermore, we explore the outcomes of new treatments for rare disorders such as gene therapy and biotherapies. The Oral Health research project is translational and combines in vitro (3D cultures, co-cultures, bone and tooth organoids…) and preclinical approaches (mouse, rat and porcine models) as well as clinical research on cohorts of patients with rare or chronic disorders. All our scientific subjects are strengthened by the presence onsite of a Micro-CT core facility with both in vivo and in vitro machines. This facility allows a thorough report of the bone or tooth microarchitecture but also the longitudinal follow-up of growth or of a repair process in a mouse model. Oral Health’s main objective aims at studying the mechanisms underlying chronic diseases (caries, periodontitis) or rare disorders affecting the oro-facial tissues and explores the outcomes of new treatments for these disorders such as gene therapy, biotherapies and tissue engineering.