TEAM 1) ORO-FACIAL PATHOPHYSIOLOGY AND TISSUE ENGINEERING (C Chaussain and S Babajko) affiliated to ITMO Physiopathologie, métabolisme, nutrition and the CSS3 address the main pathologies affecting the orofacial tissues, with inflammatory, chronic, environmental or genetic causes and to propose therapeutic strategies of regenerative medicine. This team study both rare diseases and common disorders that may appear during development or with ageing, which affect a large part of the population in France, Europe and worldwide with a high cost for health systems and for patients. These pathologies are the source of a very significant deterioration in the general health and quality of life (functional and aesthetic disorders and pain). Team 1 has a high societal and economic impact. Team 1 mainly encompass members of the MOP team and BRIO and LabNOF units, as well as several isolated researchers that develop complementary and collaborative research.

This rich interdisciplinary environment is addressed through two major themes.

Themes

Environmental and genetic oral disorders

Many patients exhibit abnormalities in the structure, number and shape of their temporary and/or permanent teeth and abnormalities in other oral tissues (oral mucosa, periodontium, tongue, etc.). These abnormalities may be due to pathogenic variants of genes involved in dental and periodontal tissues, responsible for either isolated oral manifestations or part of a syndrome. Similar abnormalities may also be related to exposure to environmental toxicants or even possibly to other type of stressors such as psycho-social stresses or even physical factors, punctual or of longer duration during the formation of teeth, and capable of altering the activity of dental cells, ameloblasts and/or odontoblasts thus generating irreversible anomalies of structure or shape.
Developing molecular approaches to identify these anomalies and studying the pathophysiological mechanisms involved are the major objectives of the projects of this theme.